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Article

ZAP-70 mRNA quantification in B-cell chronic lymphocytic leukaemia.

European journal of haematology - 1 Apr 2006

Catherwood Mark A, Matthews Christine, Niblock Roberta, Dobbin Edwina, Morris T C M, Alexander H Denis

Abstract excerpt

OBJECTIVE: The mutational status of the immunoglobulin (Ig) V(H) gene in B-cell chronic lymphocytic leukaemia (B-CLL) identifies two subgroups of patients with significantly different outcomes. We investigated the association of ZAP-70 expression with IgVH mutational status in B-CLL by quantifying ZAP-70 mRNA, to evaluate its use as a surrogate marker for mutational status. The aim of this study was to develop a...

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Share to Flow Cytometry
Share to Gene Expression Regulation, Leukemic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulin Heavy Chains

Share to Immunoglobulin Variable Region

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Reverse Transcriptase Polymerase Chain Reaction

Share to RNA, Messenger

Share to ZAP-70 Protein-Tyrosine Kinase

Source

Identifiers

PMID: 16519700
DOI: 10.1111/j.1600-0609.2005.00619.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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