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Article

Multicenter study of ZAP-70 expression in patients with B-cell chronic lymphocytic leukemia using an optimized flow cytometry method.

Haematologica - 1 Feb 2008

Gachard Nathalie, Salviat Aurélie, Boutet Catherine, Arnoulet Christine, Durrieu Françoise, Lenormand Bernard, Leprêtre Stéphane, Olschwang Sylviane, Jardin Fabrice, Lafage-Pochitaloff Marina, Penther Dominique, Sainty Danielle, Reminieras Liliane, Feuillard Jean, Béné Marie C

Abstract excerpt

BACKGROUND: Flow cytometry allows specific assessment of the expression of ZAP-70, a promising new prognostic factor in B-cell chronic lymphocytic leukemia (B-CLL), but suffers from a lack of multicenter standardization. DESIGN AND METHODS: An optimized method for direct detection of ZAP-70 in flow cytometry was tested in a multicenter fashion. Adapted for frozen cells, this method includes a normalization step...

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Identifiers

PMID: 18223290
DOI: 10.3324/haematol.11622

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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