Article
Immunohistochemical detection of ZAP70 in chronic lymphocytic leukemia predicts immunoglobulin heavy chain gene mutation status and time to progression.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Nov 2010
Admirand Joan H, Knoblock Ronald J, Coombes Kevin R, Tam Constantine, Schlette Ellen J, Wierda William G, Ferrajoli Alessandra, O'Brien Susan, Keating Michael J, Luthra Rajyalakshmi, Medeiros L Jeffrey, Abruzzo Lynne V
Abstract excerpt
Zeta-associated protein-70 (ZAP70) expression measured by flow cytometry has been proposed as a surrogate marker of the somatic mutation status of the immunoglobulin heavy chain variable region (IGHV) genes in chronic lymphocytic leukemia. However, attempts to implement this approach in clinical flow cytometry laboratories have been problematic; many commercially available antibodies give unreliable results....
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