Article
Expression of ZAP-70 protein correlates with disease stage in chronic lymphocytic leukemia and is associated with, but not generally restricted to, non-mutated Ig VH status.
Leukemia & lymphoma - 1 Oct 2004
Kim Soo-Zin, Chow Kai Uwe, Kukoc-Zivojnov Natasa, Boehrer Simone, Brieger Angela, Steimle-Grauer Susanne Annette, Harder Lana, Hoelzer Dieter, Mitrou Paris Sophokles, Weidmann Eckhart
Abstract excerpt
The mutational status of immunoglobulin variable region genes (Ig VH) is a well established prognostic parameter in chronic lymphocytic leukemia (CLL). Recently, a subset of genes with a characteristic expression profile correlating with the mutational status of B-CLLs has been identified. One of the overexpressed genes in the prognostically unfavorable group of CLL patients with unmutated Ig VH genes encodes for...
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