Clinical significance of ZAP-70 protein expression in B-cell chronic lymphocytic leukemia.

doi:10.1182/blood-2005-12-4986

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Article

Clinical significance of ZAP-70 protein expression in B-cell chronic lymphocytic leukemia.

Blood - 1 Aug 2006

Del Principe Maria Ilaria, Del Poeta Giovanni, Buccisano Francesco, Maurillo Luca, Venditti Adriano, Zucchetto Antonella, Marini Rita, Niscola Pasquale, Consalvo Maria Antonietta Irno, Mazzone Carla, Ottaviani Licia, Panetta Paola, Bruno Antonio, Bomben Riccardo, Suppo Giovanna, Degan Massimo, Gattei Valter, de Fabritiis Paolo, Cantonetti Maria, Lo Coco Francesco, Del Principe Domenico, Amadori Sergio

Abstract excerpt

The clinical course of B-cell chronic lymphocytic leukemia (B-CLL) is variable, and novel biologic parameters need to be added to the clinical staging systems to predict an indolent or aggressive outcome. We investigated the 70-kDa zeta-associated protein (ZAP-70), CD38, soluble CD23 (sCD23), and cytogenetics in 289 patients with B-CLL. Both a shorter progression-free survival (PFS) and overall survival (OS) were...

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PMID: 16601244
DOI: 10.1182/blood-2005-12-4986

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