Article
ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome, and distinct gene expression profile.
Blood - 15 Jun 2003
Wiestner Adrian, Rosenwald Andreas, Barry Todd S, Wright George, Davis R Eric, Henrickson Sarah E, Zhao Hong, Ibbotson Rachel E, Orchard Jenny A, Davis Zadie, Stetler-Stevenson Maryalice, Raffeld Mark, Arthur Diane C, Marti Gerald E, Wilson Wyndham H, Hamblin Terry J, Oscier David G, Staudt Louis M
Abstract excerpt
The presence or absence of somatic mutations in the expressed immunoglobulin heavy chain variable regions (IgVH) of chronic lymphocytic leukemia (CLL) cells provides prognostic information. Patients whose leukemic cells express unmutated IgVH regions (Ig-unmutated CLL) often have progressive disease, whereas patients whose leukemic cells express mutated IgVH regions (Ig-mutated CLL) more often have an indolent...
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