Additional genetic high-risk features such as 11q deletion, 17p deletion, and V3-21 usage characterize discordance of ZAP-70 and VH mutation status in chronic lymphocytic leukemia.

doi:10.1200/JCO.2005.03.7184

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Article

Additional genetic high-risk features such as 11q deletion, 17p deletion, and V3-21 usage characterize discordance of ZAP-70 and VH mutation status in chronic lymphocytic leukemia.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Feb 2006

Kröber Alexander, Bloehdorn Johannes, Hafner Sebastian, Bühler Andreas, Seiler Till, Kienle Dirk, Winkler Dirk, Bangerter Markus, Schlenk Richard F, Benner Axel, Lichter Peter, Döhner Hartmut, Stilgenbauer Stephan

Abstract excerpt

PURPOSE: Immunoglobulin heavy chain variable-region (VH) gene mutation status and zeta-associated protein 70 (ZAP-70) expression are correlated in chronic lymphocytic leukemia (CLL), but their concordance is variable. The goal of this study was to elucidate additional factors potentially characterizing their discordance. PATIENTS AND METHODS: We evaluated ZAP-70 expression by flow cytometry, VH status by DNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 16418492
DOI: 10.1200/JCO.2005.03.7184

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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