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Article

Comparison of ZAP-70/Syk mRNA levels with immunoglobulin heavy-chain gene mutation status and disease progression in chronic lymphocytic leukemia.

Haematologica - 1 Nov 2005

Laurenti Luca, Petlickovski Aleksandar, Rumi Carlo, Gobessi Stefania, Piccioni Paola, Tarnani Michela, Puggioni Pierluigi, Marietti Sara, Sica Simona, Leone Giuseppe, Efremov Dimitar G

Abstract excerpt

BACKGROUND AND OBJECTIVES: The protein tyrosine kinase ZAP-70 has recently emerged as a major prognostic indicator in chronic lymphocytic leukemia (CLL). ZAP-70 is structurally and functionally homologous to Syk, a key mediator of B-cell receptor signaling. We therefore evaluated ZAP-70 expressio...

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Share to Disease Progression
Share to Genes, Immunoglobulin Heavy Chain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intracellular Signaling Peptides and Proteins

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Protein-Tyrosine Kinases

Share to RNA, Messenger

Share to Syk Kinase

Share to ZAP-70 Protein-Tyrosine Kinase

Source

Identifiers

PMID: 16266901

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16266901-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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