Evaluation of ZAP-70 expression by flow cytometry in chronic lymphocytic leukemia: A multicentric international harmonization process.

doi:10.1002/cyto.b.20132

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Article

Evaluation of ZAP-70 expression by flow cytometry in chronic lymphocytic leukemia: A multicentric international harmonization process.

Cytometry. Part B, Clinical cytometry - 15 Jul 2006

Letestu Remi, Rawstron Andy, Ghia Paolo, Villamor Neus, Boeckx Nancy, Leuven Nancy Boeckx, Boettcher Sebastian, Buhl Anne Mette, Duerig Jan, Ibbotson Rachel, Kroeber Alexander, Langerak Anton, Le Garff-Tavernier Magali, Mockridge Ian, Morilla Alison, Padmore Ruth, Rassenti Laura, Ritgen Matthias, Shehata Medhat, Smolewski Piotr, Staib Peter, Ticchioni Michel, Walker Clare, Ajchenbaum-Cymbalista Florence

Abstract excerpt

The clinical course of patients with chronic lymphocytic leukemia (CLL) is heterogeneous with some patients requiring early therapy whereas others will not be treated for years. The evaluation of an individual CLL patient's prognosis remains a problematic issue. The presence or absence of somatic mutations in the IgVH genes is currently the gold-standard prognostic factor, but this technique is labor intensive...

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PMID: 16906588
DOI: 10.1002/cyto.b.20132

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