Article
ZAP-70 expression and prognosis in chronic lymphocytic leukaemia.
Lancet (London, England) - 10 Jan 2004
Orchard Jenny A, Ibbotson Rachel E, Davis Zadie, Wiestner Adrian, Rosenwald Andreas, Thomas Peter W, Hamblin Terry J, Staudt Louis M, Oscier David G
Abstract excerpt
BACKGROUND: Chronic lymphocytic leukaemia (CLL) is a heterogeneous disease; many patients never need treatment, whereas some have poor outcomes. New treatments, which can induce complete remissions, allow patients with poor outlook to be treated while they are still asymptomatic. Whether or not the IgVH gene is mutated is the best predictor of clinical outcome, but this assay is unsuited to the routine...
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