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Article

Genome shuffling of Streptomyces sp. U121 for improved production of hydroxycitric acid.

Applied microbiology and biotechnology - 1 Jan 2007

Hida Hiroyuki, Yamada Takashi, Yamada Yasuhiro

Abstract excerpt

(2S, 3R)-Hydroxycitric acid (HCA) from Hibiscus subdariffa inhibits pancreatic alpha-amylase and intestine alpha-glucosidase, leading to reduction of carbohydrate metabolism. In our previous study, Streptomyces sp. U121 was identified as a producer of (2S, 3R)-HCA [Hida et al. (2005) Bioscience, Biotechnology, and Biochemistry 69:1555-1561]. Here, we applied genome shuffling of Streptomyces sp. U121 to achieve...

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PMID: 17043823
DOI: 10.1007/s00253-006-0613-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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