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Combinatorial Effect of ARTP Mutagenesis and Ribosome Engineering on an Industrial Strain of Streptomyces albus S12 for Enhanced Biosynthesis of Salinomycin

3 Sept 2019

Abstract excerpt

Salinomycin, being an important polyketide has been widely utilized in agriculture, which inhibits the growth of pathogenic bacteria. Moreover, salinomycin has great potential in the treatment of cancer cells. Due to inherited characteristics and beneficial potential, its demand is also inclining. Therefore, there is a dire need to increase the current high demand of salinomycin. In order to obtain a high-yield...

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PMID: 31552238
DOI: 10.3389/fbioe.2019.00212

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