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Enhanced bafilomycin A1 production in Streptomyces Griseobrunneus via protoplast fusion combined with high-throughput screening.

World journal of microbiology & biotechnology - 13 Oct 2025

Sun Fei, Yuan Yuan, Chen Haimin, Fang Zhikai, Shi Yeshi, Jiang Hong, Zhou Jian

Abstract excerpt

Bafilomycin A1 (Baf A1), a macrolide antibiotic, has garnered significant attention in medical fields as a specific and reversible V-ATPase inhibitor. To enhance the screening efficiency for high-yield Baf A1 strains of Streptomyces griseobrunneus after mutagenesis, a high-throughput screening model utilizing 48-well deep plates was established, with optimal fermentation conditions being a liquid volume of 3 mL...

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PMID: 41082004
DOI: 10.1007/s11274-025-04602-5

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