Article

Enhancement of acarbose production by rational genetic engineering and process optimization in Actinoplanes sp. SIPI12-34

2022-10-10

Abstract excerpt

<h4>Background: </h4> Acarbose, as an alpha-glucosidase inhibitor, is widely used clinically to treat type II diabetes. In its industrial production, Actinoplanes sp. SE50/110 is used as the production strain. Lack of research on its regulatory mechanisms and unexplored gene targets are major obstacles to rational strain design. Here, transcriptome sequencing was applied to uncover more gene targets and rational g...

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Literature Corpus work: bfcedf3a-2c1c-5e65-a3b8-0b33e66c70b7
DOI: 10.21203/rs.3.rs-2118272/v1

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