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Article

Genome shuffling of Streptomyces roseosporus for improving daptomycin production.

Applied biochemistry and biotechnology - 1 Mar 2014

Yu Guanghai, Hu Yuansen, Hui Ming, Chen Liang, Wang Le, Liu Na, Yin Yanli, Zhao Jiang

Abstract excerpt

In this work, enhancement of daptomycin production by genome shuffling in Streptomyces roseosporus was conducted. Ultraviolet and NTG were used as mutagenizing agents to improve the volumetric productivity of the wild-type strain. Eight strains with enhanced daptomycin production were screened out as the starting population for genome shuffling. Daptomycin's production increased steadily with each round of genome...

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PMID: 24425298
DOI: 10.1007/s12010-013-0687-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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