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Metabolic engineering of Streptomyces roseosporus for increased production of clinically important antibiotic daptomycin

1 Nov 2024

Abstract excerpt

Daptomycin (DAP), a novel cyclic lipopeptide antibiotic produced by Streptomyces roseosporus, is clinically important for treatment of infections caused by multidrug-resistant Gram-positive pathogens, but the low yield hampers its large-scale industrial production. Here, we describe a combination metabolic engineering strategy for constructing a DAP high-yielding strain. Initially, we enhanced aspartate (Asp)...

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PMID: 39487765
DOI: 10.1111/1751-7915.70038

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