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Article

Streptomycin resistance-aided genome shuffling to improve doramectin productivity of Streptomyces avermitilis NEAU1069.

Journal of industrial microbiology & biotechnology - 1 Aug 2013

Zhang Ji, Wang Xiangjing, Diao Jinna, He Hairong, Zhang Yuejing, Xiang Wensheng

Abstract excerpt

Genome shuffling is an efficient approach for the rapid engineering of microbial strains with desirable industrial phenotypes. In this study, a strategy of incorporating streptomycin resistance screening into genome shuffling (GS-SR) was applied for rapid improvement of doramectin production by Streptomyces avermitilis NEAU1069. The starting mutant population was generated through treatment of the spores with...

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PMID: 23657585
DOI: 10.1007/s10295-013-1280-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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