Article
Generation of high-yield rapamycin-producing strains through protoplasts-related techniques.
Applied microbiology and biotechnology - 1 Jun 2009
Chen Xiyang, Wei Peilian, Fan Limei, Yang Dong, Zhu Xiangchen, Shen Wenhe, Xu Zhinan, Cen Peilin
Abstract excerpt
Rapamycin is a 31-member ring macrolide produced by Streptomyces hygroscopicus and has many applications in clinical medicine. In the present work, several protoplasts-related techniques including protoplasts mutation, intraspecies and interspecies protoplasts fusion were tried to improve the rapamycin productivity in S. hygroscopicus. Although mutation and fusion of different protoplasts of S. hygroscopicus did...
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