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Article

Genome shuffling of Streptomyces viridochromogenes for improved production of avilamycin.

Applied microbiology and biotechnology - 1 Jan 2013

Lv Xing-An, Jin Ying-Yan, Li Yu-Dong, Zhang Hong, Liang Xin-Le

Abstract excerpt

Avilamycin is one of EU-approved antimicrobial agents in feed industry to inhibit the growth of multidrug-resistant Gram-positive bacteria. Here, we applied a process of combining ribosome engineering and genome shuffling to achieve rapid improvement of avilamycin production in Streptomyces viridochromogenes AS 4.126. The starting mutant population was generated by (60)Co γ-irradiation treatments of the spores....

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PMID: 22911092
DOI: 10.1007/s00253-012-4322-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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