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Article

Construction of Streptomyces coelicolor A3(2) mutants that exclusively produce NA4/NA6 intermediates of agarose metabolism through mutation induction.

Scientific reports - 3 Nov 2023

Kim Jina, Kim Eun Joo, Ko Hye-Jeong, Lee Yeon-Hee, Hong Soon-Kwang, Shin Miyoung, Lee Je Hyeon, Kwak Woori

Abstract excerpt

NA4/NA6, an intermediate degradation product of β-agarase, is a high value-added product with anticancer, anti-obesity, and anti-diabetic effects. Therefore, a method that enables the efficient production of NA4/NA6 would be useful from economic and medical perspectives. In this study, we aimed to generate a Streptomyces coelicolor A3(2) mutant M22-2C43 that produces NA4/NA6 as a final product; this method serves...

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Identifiers

PMID: 37923760
DOI: 10.1038/s41598-023-46410-7
PMCID: PMC10624881

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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