The "Warrior" COMT Val/Met Genotype Occurs in Greater Frequencies in Mixed Martial Arts Fighters Relative to Controls.

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The "Warrior" COMT Val/Met Genotype Occurs in Greater Frequencies in Mixed Martial Arts Fighters Relative to Controls.

Journal of sports science & medicine - 1 Mar 2020

Tartar Jaime L, Cabrera Dominick, Knafo Sarah, Thomas Julius D, Antonio Jose, Peacock Corey A

Abstract excerpt

A functional single-nucleotide polymorphism (SNP) in the catechol-O-methyltransferase (COMT) gene (rs4680) is a gene variant that has been shown to predict the ability to maintain cognitive agility during combat and competition. Critically, COMT Met (low-activity; high dopamine) allele carriers outperform Val (high-activity; low dopamine) homozygotes on a variety of cognitive tasks. However, the relationship...

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PMID: 32132825
PMCID: PMC7039020

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