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Article

Catechol-O-methyltransferase val158met genotype affects processing of emotional stimuli in the amygdala and prefrontal cortex.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 26 Jan 2005

Smolka Michael N, Schumann Gunter, Wrase Jana, Grüsser Sabine M, Flor Herta, Mann Karl, Braus Dieter F, Goldman David, Büchel Christian, Heinz Andreas

Abstract excerpt

Catechol-O-methyltransferase (COMT) degrades the catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. A functional polymorphism in the COMT gene (val158met) accounts for a fourfold variation in enzyme activity. The low-activity met158 allele has been associated with improved working memory but with higher risk for anxiety-related behaviors. Using functional magnetic resonance imaging, we...

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Identifiers

PMID: 15673663
DOI: 10.1523/JNEUROSCI.1792-04.2005
PMCID: PMC6725630

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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