Article
Cationic amino acid transporter 2 regulates inflammatory homeostasis in the lung.
Proceedings of the National Academy of Sciences of the United States of America - 3 Oct 2006
Rothenberg Marc E, Doepker Matthew P, Lewkowich Ian P, Chiaramonte Monica G, Stringer Keith F, Finkelman Fred D, MacLeod Carol L, Ellies Lesley G, Zimmermann Nives
Abstract excerpt
Arginine is an amino acid that serves as a substrate for nitric oxide synthase and arginase. As such, arginine has the potential to influence diverse fundamental processes in the lung. Here we report that the arginine transport protein, cationic amino acid transporter (CAT)2, has a critical role in regulating lung inflammatory responses. Analysis of CAT2-deficient mice revealed spontaneous inflammation in the...
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