Article
Enhanced Th2 cell differentiation and function in the absence of Nox2.
Allergy - 1 Feb 2017
Kwon B-I, Kim T W, Shin K, Kim Y H, Yuk C M, Yuk J-M, Shin D-M, Jo E-K, Lee C-H, Lee S-H
Abstract excerpt
BACKGROUND: Patients with chronic granulomatous disease (CGD), whom inherit abnormal function of NADPH oxidase 2 (Nox2), suffer from hyperinflammatory responses in lung as well as bacterial and fungal infection. There have been studies to reveal the function of Nox2 in hyperinflammatory diseases, especially in asthma, but the exact role of Nox2 in asthma is still unclear and controversial. Therefore, we attempted...
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