Article
In vivo depletion of CD206+ M2 macrophages exaggerates lung injury in endotoxemic mice.
The American journal of pathology - 1 Jan 2015
Kambara Kenta, Ohashi Wakana, Tomita Kengo, Takashina Michinori, Fujisaka Shiho, Hayashi Ryuji, Mori Hisashi, Tobe Kazuyuki, Hattori Yuichi
Abstract excerpt
Although phenotypically polarized macrophages are now generally classified into two major subtypes termed proinflammatory M1 and anti-inflammatory M2 macrophages, a contributory role of lung M2 macrophages in the pathophysiological features of acute lung injury is not fully understood. Herein, we show in an endotoxemic murine model that M2 macrophages serve as key anti-inflammatory cells that play a regulatory...
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