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Article

Impaired Host Defense in Mice Lacking ONZIN

1 Apr 2007

Abstract excerpt

ONZIN is a small, cysteine-rich peptide of unique structure that is conserved in all vertebrates examined to date. We show that ONZIN is expressed at high levels in epithelial cells of the intestinal tract, the lung, and in cells of the immune system including macrophages and granulocytes. Because this pattern of expression is suggestive of a role in innate immune function, we have generated mice lacking this...

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PMID: 17404296
DOI: 10.4049/jimmunol.178.8.5132

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