Article
Identification of nitric oxide synthase as a protective locus against tuberculosis.
Proceedings of the National Academy of Sciences of the United States of America - 13 May 1997
MacMicking J D, North R J, LaCourse R, Mudgett J S, Shah S K, Nathan C F
Abstract excerpt
Mutagenesis of the host immune system has helped identify response pathways necessary to combat tuberculosis. Several such pathways may function as activators of a common protective gene: inducible nitric oxide synthase (NOS2). Here we provide direct evidence for this gene controlling primary Mycobacterium tuberculosis infection using mice homozygous for a disrupted NOS2 allele. NOS2(-/-) mice proved highly...
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