Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Conditional regulation of cyclooxygenase-2 in tracheobronchial epithelial cells modulates pulmonary immunity.

Clinical and experimental immunology - 1 Nov 2007

Park G Y, Hu N, Wang X, Sadikot R T, Yull F E, Joo M, Peebles R S, Blackwell T S, Christman J W

Abstract excerpt

Cyclooxygenase-2 (COX-2) gene expression in the lung is induced in pathological conditions such as asthma and pneumonia; however, the exact impact of COX-2 gene expression in the airway in regulating inflammatory and immunological response in the lung is not understood. To define a physiological role of inducible COX-2 in airway epithelial cells, we developed a novel line of transgenic mice, referred to as...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bronchi
Share to Cyclooxygenase 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dinoprostone

Share to Immunity, Mucosal

Share to Prostaglandins

Share to Pseudomonas Infections

Share to Respiratory Mucosa

Share to Trachea

Source

Open in PubMed Open full text

Identifiers

PMID: 17672868
DOI: 10.1111/j.1365-2249.2007.03478.x
PMCID: PMC2219354

Genes

PGD
PGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Conditional regulation of cyclooxygenase-2 in tracheobronchial epithelial cells modulates pulmonary immunity.PMID 17672868Read ↗

Conditional knockout mouse for tissue-specific disruption of the cyclooxygenase-2 (Cox-2) geneSemantic proximity Read ↗

Transgenic expression of cyclooxygenase-2 (COX2) causes premature aging phenotypes in mice.Semantic proximity Read ↗

Transgenic cyclooxygenase-2 overexpression sensitizes mouse skin for carcinogenesis.Semantic proximity Read ↗

Trefoil Factor-2 Is an Allergen-Induced Gene Regulated by Th2 Cytokines and STAT6 in the LungSemantic proximity Read ↗

Modulation of Lung Epithelial Cell Function Using Conditional and Inducible Transgenic Approaches.Semantic proximity Read ↗

Cyclooxygenase-deficient mice. A summary of their characteristics and susceptibilities to inflammation and carcinogenesis.Semantic proximity Read ↗

Immunoregulatory effects of regulated, lung-targeted expression of IL-10 in vivo.Semantic proximity Read ↗

Cystic duct dilatations and proliferative epithelial lesions in mouse mammary glands upon keratin 5 promoter-driven overexpression of cyclooxygenase-2.Semantic proximity Read ↗

Transgenic modelling of cytokine polarization in the lung.Semantic proximity Read ↗

Susceptibility of cyclooxygenase-2-deficient mice to pulmonary fibrogenesis.Semantic proximity Read ↗

Phenotypes of the COX-deficient mice indicate physiological and pathophysiological roles for COX-1 and COX-2.Semantic proximity Read ↗

State of the Art. Mechanistic Heterogeneity in Chronic Obstructive Pulmonary Disease: Insights from Transgenic MiceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.