Article
NO2 inhalation induces maturation of pulmonary CD11c+ cells that promote antigenspecific CD4+ T cell polarization.
Respiratory research - 26 Jul 2010
Hodgkins Samantha R, Ather Jennifer L, Paveglio Sara A, Allard Jenna L, LeClair Laurie A Whittaker, Suratt Benjamin T, Boyson Jonathan E, Poynter Matthew E
Abstract excerpt
BACKGROUND: Nitrogen dioxide (NO2) is an air pollutant associated with poor respiratory health, asthma exacerbation, and an increased likelihood of inhalational allergies. NO2 is also produced endogenously in the lung during acute inflammatory responses. NO2 can function as an adjuvant, allowing for allergic sensitization to an innocuous inhaled antigen and the generation of an antigen-specific Th2 immune...
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