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Article

Arginine metabolic control of airway inflammation.

JCI insight - 30 Jan 2020

Asosingh Kewal, Lauruschkat Chris D, Alemagno Mario, Frimel Matthew, Wanner Nicholas, Weiss Kelly, Kessler Sean, Meyers Deborah A, Bennett Carole, Xu Weiling, Erzurum Serpil

Abstract excerpt

Inducible nitric oxide synthase (iNOS) and arginase-2 (ARG2) share a common substrate, arginine. Higher expression of iNOS and exhaled NO are linked to airway inflammation in patients. iNOS deletion in animal models suggests that eosinophilic inflammation is regulated by arginine metabolism. Moreover, ARG2 is a regulator of Th2 response, as shown by the development of severe eosinophilic inflammation in ARG2-/-...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31996482
DOI: 10.1172/jci.insight.127801
PMCID: PMC7098726

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