Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Upf1/Upf2 regulation of 3' untranslated region splice variants of AUF1 links nonsense-mediated and A+U-rich element-mediated mRNA decay.

Molecular and cellular biology - 1 Dec 2006

Banihashemi Lili, Wilson Gerald M, Das Neha, Brewer Gary

Abstract excerpt

AUF1 is an RNA-binding protein that targets mRNAs containing A+U-rich elements (AREs) for rapid cytoplasmic turnover. Alternative pre-mRNA splicing produces five variants of AUF1 mRNA that differ in the composition of their 3'-untranslated regions (3'-UTRs). Previous work suggested that this heterogeneity in 3'-UTR sequence could regulate AUF1 expression by two potential mechanisms. First, AUF1 may regulate its...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3' Untranslated Regions
Share to Alternative Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to HeLa Cells

Share to Models, Biological

Share to RNA-Binding Proteins

Share to RNA Helicases

Share to Trans-Activators

Source

Open in PubMed Open full text

Identifiers

PMID: 17000771
DOI: 10.1128/MCB.02251-05
PMCID: PMC1636803

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Upf1/Upf2 regulation of 3' untranslated region splice variants of AUF1 links nonsense-mediated and A+U-rich element-mediated mRNA decay.PMID 17000771Read ↗

Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay.Semantic proximity Read ↗

Molecular basis of neurodevelopmental disorder-causing mutation in nonsense-mediated mRNA decay factor UPF3BSemantic proximity Read ↗

Cloning and characterization of HUPF1, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 proteinSemantic proximity Read ↗

UPF3A is a ubiquitously expressed NMD factor among mouse tissuesSemantic proximity Read ↗

Upf proteins: highly conserved factors involved in nonsense mRNA mediated decay.Semantic proximity Read ↗

Nonsense-mediated mRNA decay and development: shoot the messenger to survive?Semantic proximity Read ↗

Dynamic RNA binding and unfolding by nonsense-mediated mRNA decay factor UPF2Semantic proximity Read ↗

UPF3A is dispensable for nonsense-mediated mRNA decay in mouse pluripotent and somatic cellsSemantic proximity Read ↗

An alternative UPF1 isoform drives conditional remodeling of nonsense-mediated mRNA decaySemantic proximity Read ↗

Separable roles for rent1/hUpf1 in altered splicing and decay of nonsense transcripts.Semantic proximity Read ↗

UPF1-From mRNA Degradation to Human Disorders.Semantic proximity Read ↗

Drosophila Upf1 and Upf2 loss of function inhibits cell growth and causes animal death in a Upf3-independent manner.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.