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Article

Separable roles for rent1/hUpf1 in altered splicing and decay of nonsense transcripts.

Science (New York, N.Y.) - 11 Oct 2002

Mendell Joshua T, ap Rhys Colette M J, Dietz Harry C

Abstract excerpt

The mechanism by which disruption of reading frame can influence pre-messenger RNA (pre-mRNA) processing is poorly understood. We assessed the role of factors essential for nonsense-mediated mRNA decay (NMD) in nonsense-mediated altered splicing (NAS) with the use of RNA interference (RNAi) in mammalian cells. Inhibition of rent1/hUpf1 expression abrogated both NMD and NAS of nonsense T cell receptor beta...

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Source

Identifiers

PMID: 12228722
DOI: 10.1126/science.1074428

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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