Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The high-activity Val allele of the catechol-O-methyltransferase gene predicts greater cognitive deterioration in patients with psychosis.

Psychiatric genetics - 1 Oct 2006

Mata Ignacio, Arranz Maria J, Staddon Susan, Lopez-Ilundain Jose M, Tabares-Seisdedos Rafael, Murray Robin M

Abstract excerpt

The objective of this study was to examine whether the functional genetic polymorphism Val158Met in the catechol-O-methyltransferase (COMT) gene influences cognitive deterioration in a sample of patients with psychosis under treatment with atypical antipsychotics. Eighty-seven patients with psychosis were genotyped for this polymorphism and were assessed with three Wechsler Adult Intelligence Scale (WAIS)-III...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Alleles

Share to Catechol O-Methyltransferase

Share to Cognition Disorders

Share to COMT gene

Share to Psychotic Disorders

Share to Valine

Source

Identifiers

PMID: 16969277
DOI: 10.1097/01.ypg.0000218626.26622.a2

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The high-activity Val allele of the catechol-O-methyltransferase gene predicts greater cognitive deterioration in patients with psychosis.PMID 16969277Read ↗

No association between the Catechol-O-Methyltransferase (COMT) val158met polymorphism and cognitive improvement following cognitive remediation therapy (CRT) in schizophrenia.Semantic proximity Read ↗

Effects of COMT genotype on cognitive ability and functional capacity in individuals with schizophrenia.Semantic proximity Read ↗

Catechol-O-methyltransferase polymorphisms and some implications for cognitive therapeutics.Semantic proximity Read ↗

COMT genotype and response to cognitive remediation in schizophrenia.Semantic proximity Read ↗

COMT val108/158met genotype, cognitive function, and cognitive improvement with clozapine in schizophrenia.Semantic proximity Read ↗

Catechol-O-methyltransferase gene polymorphism is associated with risk of psychosis in Alzheimer Disease.Semantic proximity Read ↗

Meta-analysis of the cognitive effects of the catechol-O-methyltransferase gene Val158/108Met polymorphism.Semantic proximity Read ↗

Catechol-O-methyltransferase Val158Met genotype variation is associated with prefrontal-dependent task performance in schizotypal personality disorder patients and comparison groups.Semantic proximity Read ↗

Catechol-O-methyltransferase gene Val/Met functional polymorphism and risk of schizophrenia: a large-scale association study plus meta-analysis.Semantic proximity Read ↗

COMT (Val(158/108)Met) genotype moderates the impact of antipsychotic medication on verbal IQ in twins with schizophrenia.Semantic proximity Read ↗

Neurocognitive correlates of the COMT Val(158)Met polymorphism in chronic schizophrenia.Semantic proximity Read ↗

Catechol-O-methyltransferase genotype differentially contributes to the flexibility and stability of cognitive sets in patients with psychotic disorders and their first-degree relatives.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.