Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Catechol-O-methyltransferase gene Val/Met functional polymorphism and risk of schizophrenia: a large-scale association study plus meta-analysis.

Biological psychiatry - 15 Jan 2005

Fan Jin-Bo, Zhang Chang-Shun, Gu Niu-Fan, Li Xing-Wang, Sun Wei-Wei, Wang Hong-Yan, Feng Guo-Yin, St Clair David, He Lin

Abstract excerpt

BACKGROUND: A common functional polymorphism (Val/Met) in the catechol-O-methyltransferase gene (COMT) that markedly affects enzyme activity has been shown to affect executive cognition and the physiology of the prefrontal cortex in humans. It is hypothesized that the high activity Val allele slightly increases risk for schizophrenia through its effect on dopamine-mediated prefrontal information processing....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution
Share to Asian People

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Catechol O-Methyltransferase

Share to Genetics, Population

Share to Methionine

Share to Schizophrenia

Share to Valine

Source

Identifiers

PMID: 15652872
DOI: 10.1016/j.biopsych.2004.10.018

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Catechol-O-methyltransferase gene Val/Met functional polymorphism and risk of schizophrenia: a large-scale association study plus meta-analysis.PMID 15652872Read ↗

Association between a functional catechol O-methyltransferase gene polymorphism and schizophrenia: meta-analysis of case-control and family-based studies.Semantic proximity Read ↗

Functional catechol-O-methyltransferase gene polymorphism and susceptibility to schizophrenia.Semantic proximity Read ↗

The Role of a Catechol-O-Methyltransferase (COMT) Val158Met Genetic Polymorphism in Schizophrenia: A Systematic Review and Updated Meta-analysis on 32,816 Subjects.Semantic proximity Read ↗

A novel protein isoform of catechol O-methyltransferase (COMT): brain expression analysis in schizophrenia and bipolar disorder and effect of Val158Met genotype.Semantic proximity Read ↗

Association of the functional polymorphism in the catechol-O-methyltransferase gene with schizophrenia in the three ethnic groups of the Malaysian population.Semantic proximity Read ↗

Heterozygosity at catechol-O-methyltransferase Val158Met and schizophrenia: new data and meta-analysis.Semantic proximity Read ↗

Association between Val108/158 Met polymorphism of the COMT gene and schizophrenia.Semantic proximity Read ↗

No associations exist between five functional polymorphisms in the catechol-O-methyltransferase gene and schizophrenia in a Japanese population.Semantic proximity Read ↗

The effects of catechol-O-methyltransferase single nucleotide polymorphisms on positive and negative symptoms of schizophrenia: A systematic review and meta-analysis.Semantic proximity Read ↗

Association analysis of a functional catechol-o-methyltransferase gene polymorphism in schizophrenic patients in Taiwan.Semantic proximity Read ↗

Association of catechol-O-methyltransferase gene polymorphisms with schizophrenia and negative symptoms in a Chinese population.Semantic proximity Read ↗

Meta-analysis of association between genetic variants in COMT and schizophrenia: an update.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.