Article
Catechol-O-methyltransferase Val158Met genotype variation is associated with prefrontal-dependent task performance in schizotypal personality disorder patients and comparison groups.
Psychiatric genetics - 1 Jun 2006
Minzenberg Michael J, Xu Ke, Mitropoulou Vivian, Harvey Philip D, Finch Thembi, Flory Janine D, New Antonia S, Goldman David, Siever Larry J
Abstract excerpt
OBJECTIVE: A single-nucleotide polymorphism of the gene coding for catechol-O-methyltransferase (COMT Val(158)Met) is associated with prefrontal-dependent task performance in schizophrenia. We evaluated the relationship of the COMT genotype with diagnostic status and cognitive performance in schizotypal personality disorder. METHODS: Unmedicated outpatients with schizotypal personality disorder (SPD; n = 67) and...
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