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Article

COMT genotype and response to cognitive remediation in schizophrenia.

Schizophrenia research - 1 Oct 2015

Lindenmayer Jean-Pierre, Khan Anzalee, Lachman Herbert, McGurk Susan R, Goldring Abraham, Thanju Amod, Kaushik Saurabh

Abstract excerpt

BACKGROUND: A functional polymorphism of the catechol-O-methyltransferase (COMT) gene (Val158Met) partially appears to influence cognitive performance in schizophrenia subjects and healthy controls by modulating prefrontal dopaminergic activity. This study evaluated the association of the COMT Val108/158 Met genotype with response to computerized neurocognitive remediation (CRT). METHOD: 145 subjects with...

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Identifiers

PMID: 26255563
DOI: 10.1016/j.schres.2015.07.037
PMCID: PMC4591188

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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