Article
Catechol-O-methyltransferase gene polymorphism is associated with risk of psychosis in Alzheimer Disease.
Neuroscience letters - 11 Nov 2004
Borroni Barbara, Agosti Chiara, Archetti Silvana, Costanzi Chiara, Bonomi Silvia, Ghianda Diego, Lenzi Gian Luigi, Caimi Luigi, Di Luca Monica, Padovani Alessandro
Abstract excerpt
There is emerging evidence that psychosis in Alzheimer Disease (AD) represents a clinically relevant phenotype with a distinct biological process. It has been reported that a functional polymorphism of the catechol-O-methyltransferase (COMT) gene predisposes to an increased risk for schizophrenia and likely to psychosis susceptibility. Aim of this study was to evaluate functional COMT genetic variation as a risk...
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