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Article

Structural basis and functional consequence of Helicobacter pylori CagA multimerization in cells.

The Journal of biological chemistry - 27 Oct 2006

Ren Shumei, Higashi Hideaki, Lu Huaisheng, Azuma Takeshi, Hatakeyama Masanori

Abstract excerpt

Helicobacter pylori cagA-positive strains are associated with gastric adenocarcinoma. The cagA gene product CagA is delivered into gastric epithelial cells where it localizes to the plasma membrane and undergoes tyrosine phosphorylation at the EPIYA-repeat region, which contains the EPIYA-A segment, EPIYA-B segment, and Western CagA-specific EPIYA-C or East Asian CagA-specific EPIYA-D segment. In host cells, CagA...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 16954210
DOI: 10.1074/jbc.M606172200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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