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Structure and function of Helicobacter pylori CagA, the first-identified bacterial protein involved in human cancer

1 Jan 2017

Abstract excerpt

Chronic infection with Helicobacter pylori cagA-positive strains is the strongest risk factor of gastric cancer. The cagA gene-encoded CagA protein is delivered into gastric epithelial cells via bacterial type IV secretion, where it undergoes tyrosine phosphorylation at the Glu-Pro-Ile-Tyr-Ala (EPIYA) motifs. Delivered CagA then acts as a non-physiological scaffold/hub protein by interacting with multiple host...

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PMID: 28413197
DOI: 10.2183/pjab.93.013

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