Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A specific A/T polymorphism in Western tyrosine phosphorylation B-motifs regulates Helicobacter pylori CagA epithelial cell interactions.

PLoS pathogens - 1 Feb 2015

Zhang Xue-Song, Tegtmeyer Nicole, Traube Leah, Jindal Shawn, Perez-Perez Guillermo, Sticht Heinrich, Backert Steffen, Blaser Martin J

Abstract excerpt

Helicobacter pylori persistently colonizes the human stomach, with mixed roles in human health. The CagA protein, a key host-interaction factor, is translocated by a type IV secretion system into host epithelial cells, where its EPIYA tyrosine phosphorylation motifs (TPMs) are recognized by host...

Topics

Amino Acid Motifs
Antigens, Bacterial
Bacterial Proteins
Cell Line
Coculture Techniques
Epithelial Cells
Helicobacter pylori
Host-Pathogen Interactions
Humans
Immunoblotting
Immunoprecipitation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phosphorylation

Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 25646814
DOI: 10.1371/journal.ppat.1004621
PMCID: PMC4412286

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-25646814-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A specific A/T polymorphism in Western tyrosine phosphorylation B-motifs regulates Helicobacter pylori CagA epithelial cell interactions.PMID 25646814Read ↗

Systematic Analysis of Phosphotyrosine Antibodies Recognizing Single Phosphorylated EPIYA-Motifs in CagA of Western-Type Helicobacter pylori StrainsSemantic proximity Read ↗

Systematic analysis of phosphotyrosine antibodies recognizing single phosphorylated EPIYA-motifs in CagA of East Asian-type Helicobacter pylori strainsSemantic proximity Read ↗

Deregulation of β‐catenin signal by <i>Helicobacter pylori</i> CagA requires the CagA‐multimerization sequenceSemantic proximity Read ↗

EPIYA motif is a membrane-targeting signal of Helicobacter pylori virulence factor CagA in mammalian cells.Semantic proximity Read ↗

Anthropological and clinical implications for the structural diversity of the Helicobacter pylori CagA oncoproteinSemantic proximity Read ↗

Structural basis and functional consequence of Helicobacter pylori CagA multimerization in cells.Semantic proximity Read ↗

Helicobacter pylori CagA: analysis of sequence diversity in relation to phosphorylation motifs and implications for the role of CagA as a virulence factor.Semantic proximity Read ↗

Natural variant of the <i>Helicobacter pylori</i> CagA oncoprotein that lost the ability to interact with <scp>PAR</scp>1Semantic proximity Read ↗

Helicobacter pylori CagA containing ITAM-like sequences localized to lipid rafts negatively regulates VacA-induced signaling in vivo.Semantic proximity Read ↗

Characterization of East-Asian Helicobacter pylori encoding Western EPIYA-ABC CagA.Semantic proximity Read ↗

Structure and function of Helicobacter pylori CagA, the first-identified bacterial protein involved in human cancerSemantic proximity Read ↗

A Comprehensive Sequence and Disease Correlation Analyses for the C-Terminal Region of CagA Protein of Helicobacter pyloriSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.