<i>Helicobacter pylori</i> CagA—a bacterial intruder conspiring gastric carcinogenesis

doi:10.1002/ijc.21831

Article

<i>Helicobacter pylori</i> CagA—a bacterial intruder conspiring gastric carcinogenesis

23 Mar 2006

Abstract excerpt

Infection with cagA-positive Helicobacter pylori (H. pylori) is associated with the development of gastric adenocarcinoma. The cagA gene product CagA is delivered from the bacterium into the cytoplasm of the bacterium-attached gastric epithelial cell via the type-IV secretion system. Upon membrane localization and subsequent tyrosine phosphorylation by Src family kinases, translocated CagA functions as a...

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