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Article

Structural and functional diversity in the PAR1b/MARK2-binding region of Helicobacter pylori CagA.

Cancer science - 1 Oct 2008

Lu Huai-Sheng, Saito Yasuhiro, Umeda Mayumi, Murata-Kamiya Naoko, Zhang Hong-Mei, Higashi Hideaki, Hatakeyama Masanori

Abstract excerpt

Helicobacter pylori (H. pylori) cagA-positive strains are associated with gastritis, peptic ulcerations, and gastric adenocarcinoma. Upon delivery into gastric epithelial cells, the cagA-encoded CagA protein specifically binds and aberrantly activates SHP-2 oncoprotein in a manner that is dependent on CagA tyrosine phosphorylation. CagA-deregulated SHP-2 then elicits aberrant Erk activation while causing an...

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Source

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Identifiers

PMID: 19016760
DOI: 10.1111/j.1349-7006.2008.00950.x
PMCID: PMC11158609

Genes

MARK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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