<i>Helicobacter pylori</i> CagA: a new paradigm for bacterial carcinogenesis

doi:10.1111/j.1349-7006.2005.00130.x

Article

<i>Helicobacter pylori</i> CagA: a new paradigm for bacterial carcinogenesis

1 Dec 2005

Abstract excerpt

Infection with CagA-positive Helicobacter pylori is associated with the development of gastric adenocarcinoma. The CagA gene product CagA is injected directly from the bacterium into the bacterium-attached gastric epithelial cells via the type-IV secretion system. Upon membrane localization and subsequent tyrosine phosphorylation by Src family kinases, CagA functions as a scaffolding adaptor and interacts with a...

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