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Deregulation of β‐catenin signal by <i>Helicobacter pylori</i> CagA requires the CagA‐multimerization sequence

24 Oct 2007

Abstract excerpt

Infection with Helicobacter pylori cagA-positive strains causes gastritis and peptic ulceration and is associated with gastric adenocarcinoma. The cagA gene product CagA is delivered into gastric epithelial cells, where it undergoes tyrosine phosphorylation by Src family kinases at the C-terminal EPIYA-repeat region. Tyrosine-phosphorylated CagA specifically binds and activates SHP-2 tyrosine phosphatase, causing...

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Identifiers

PMID: 17960618
DOI: 10.1002/ijc.23190

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