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Article

Helicobacter pylori CagA induces Ras-independent morphogenetic response through SHP-2 recruitment and activation.

The Journal of biological chemistry - 23 Apr 2004

Higashi Hideaki, Nakaya Akihiro, Tsutsumi Ryouhei, Yokoyama Kazuyuki, Fujii Yumiko, Ishikawa Susumu, Higuchi Megumi, Takahashi Atsushi, Kurashima Yo, Teishikata Yasuhiro, Tanaka Shinya, Azuma Takeshi, Hatakeyama Masanori

Abstract excerpt

The CagA protein of Helicobacter pylori, which is injected from the bacteria into bacteria-attached gastric epithelial cells, is associated with gastric carcinoma. CagA is tyrosine-phosphorylated by Src family kinases, binds the SH2 domain-containing SHP-2 phosphatase in a tyrosine phosphorylation-dependent manner, and deregulates its enzymatic activity. We established AGS human gastric epithelial cells that...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Protein Tyrosine Phosphatase, Non-Receptor Type 11

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Identifiers

PMID: 14963045
DOI: 10.1074/jbc.M309964200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Helicobacter pylori CagA induces Ras-independent morphogenetic response through SHP-2 recruitment and activation.PMID 14963045Read ↗

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