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Anthropological and clinical implications for the structural diversity of the Helicobacter pylori CagA oncoprotein

11 Sept 2010

Abstract excerpt

Helicobacter pylori CagA is the first bacterial oncoprotein to be identified in relation to human cancer. CagA is delivered into gastric epithelial cells through a bacterial type IV secretion system and localizes to the plasma membrane, where it undergoes tyrosine phosphorylation by host cell kinases. Membrane-localized CagA then mimics mammalian scaffold proteins and perturbs a number of host signaling pathways...

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PMID: 20942897
DOI: 10.1111/j.1349-7006.2010.01743.x

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