Deregulation of SHP-2 tyrosine phosphatase by the Helicobacter pylori virulence factor CagA.

doi:10.2302/kjm.51.supplement2_26

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Article

Deregulation of SHP-2 tyrosine phosphatase by the Helicobacter pylori virulence factor CagA.

The Keio journal of medicine - 1 Dec 2002

Hatakeyama Masanori

Abstract excerpt

Helicobacter pylori (H. pylori) is estimated to infect about half of the world population. It causes gastric diseases ranging from gastritis to cancer and has been classified as a class I carcinogen by WHO. However, little is known about the molecular mechanisms by which H. pylori induces pathogenesis. CagA is the product of the cagA gene carried among virulent H. pylori strains and is associated with severe...

Topics

Antigens, Bacterial
Bacterial Proteins
Cell Division
Down-Regulation
Epithelial Cells
Helicobacter pylori
Humans
Intracellular Signaling Peptides and Proteins
Models, Biological
Models, Genetic
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phosphorylation

Polymorphism, Genetic

Protein Tyrosine Phosphatase, Non-Receptor Type 11

Protein Tyrosine Phosphatases

Signal Transduction

Stomach

Transfection

Source

Open in PubMed

Identifiers

PMID: 12528933
DOI: 10.2302/kjm.51.supplement2_26

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-12528933-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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