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Article

Potentiation of Helicobacter pylori CagA protein virulence through homodimerization.

The Journal of biological chemistry - 23 Sept 2011

Nagase Lisa, Murata-Kamiya Naoko, Hatakeyama Masanori

Abstract excerpt

Chronic infection with Helicobacter pylori cagA-positive strains is associated with atrophic gastritis, peptic ulceration, and gastric carcinoma. The cagA gene product, CagA, is delivered into gastric epithelial cells via type IV secretion, where it undergoes tyrosine phosphorylation at the EPIYA motifs. Tyrosine-phosphorylated CagA binds and aberrantly activates the oncogenic tyrosine phosphatase SHP2, which...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21813645
DOI: 10.1074/jbc.M111.258673
PMCID: PMC3190882

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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