Article
EPIYA motif is a membrane-targeting signal of Helicobacter pylori virulence factor CagA in mammalian cells.
The Journal of biological chemistry - 17 Jun 2005
Higashi Hideaki, Yokoyama Kazuyuki, Fujii Yumiko, Ren Shumei, Yuasa Hitomi, Saadat Iraj, Murata-Kamiya Naoko, Azuma Takeshi, Hatakeyama Masanori
Abstract excerpt
Helicobacter pylori contributes to the development of peptic ulcers and atrophic gastritis. Furthermore, H. pylori strains carrying the cagA gene are more virulent than cagA-negative strains and are associated with the development of gastric adenocarcinoma. The cagA gene product, CagA, is translocated into gastric epithelial cells and localizes to the inner surface of the plasma membrane, in which it undergoes...
Topics
- Amino Acid Motifs
- Amino Acid Sequence
- Antigens, Bacterial
- Bacterial Proteins
- Binding Sites
- Blotting, Western
- Cell Line
- Cell Membrane
- Cytoplasm
- Epithelium