Article
Orange flavonoid hesperetin modulates cardiac hERG potassium channel via binding to amino acid F656.
Nutrition, metabolism, and cardiovascular diseases : NMCD - 1 Nov 2007
Scholz Eberhard P, Zitron Edgar, Kiesecker Claudia, Thomas Dierk, Kathöfer Sven, Kreuzer Jörg, Bauer Alexander, Katus Hugo A, Remppis Andrew, Karle Christoph A, Greten Johannes
Abstract excerpt
BACKGROUND AND AIMS: Hesperetin belongs to the flavonoid subgroup classified as citrus flavonoids and is the main flavonoid in oranges. A high dietary intake of flavonoids has been associated with a significant reduction in cardiovascular mortality. HERG potassium channels play a major role in cardiac repolarisation and represent the most important pharmacologic target of both antiarrhythmic and proarrhythmic...
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